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nonlinear regression model log[agonist] vs response-variable slope (four parameters)  (GraphPad Software Inc)


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    GraphPad Software Inc nonlinear regression model log[agonist] vs response-variable slope (four parameters)
    Nonlinear Regression Model Log[Agonist] Vs Response Variable Slope (Four Parameters), supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/nonlinear+regression+%E2%80%98log+agonist+vs%2E+response%E2%80%99+model+with+variable+slope/log+agonist++vs++response/10__2147_slash_ijn__s495259-120-9-16
    Average 90 stars, based on 1 article reviews
    nonlinear regression model log[agonist] vs response-variable slope (four parameters) - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Concentration Assay:

    Article Title: Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor
    Article Snippet: .. The concentration response curves were fitted to a nonlinear regression ‘log agonist vs. response’ model with variable slope using Graphpad Prism v9. .. HEK293 cells (ATCC CRL-1573) were transfected in suspension with DNA encoding WT and mutant CaSR in concentrations ranging from 25–100 ng per ml of cell suspension to obtain similar surface expression levels of WT and mutant receptors.

    Article Title: Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.
    Article Snippet: The calcium-sensing receptor (CaSR) is a family C G-protein-coupled receptor (GPCR) that has a central role in regulating systemic calcium homeostasis.. Here we use cryo-electron microscopy and functional assays to investigate the activation of human CaSR embedded in lipid nanodiscs and its coupling to functional Gi versus Gq proteins in the presence and absence of the calcimimetic drug cinacalcet.. Highresolution structures show that both Gi and Gq drive additional conformational changes in the activated CaSR dimer to stabilize a more extensive asymmetric interface of the seven-transmembrane domain (7TM) that involves key protein– lipid interactions.



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